Identification of a neuron-specific ferroptosis in the neurodegenerative mucopolysaccharidosis III model

Identification of a neuron-specific ferroptosis in the neurodegenerative mucopolysaccharidosis III model Sanfilippo syndrome (MPSIII) is a neurodegenerative disorder caused by enzyme deficiencies, leading to the toxic accumulation of heparan sulfate oligosaccharides in the brain. Emerging evidence suggests that ferroptosis, an iron-dependent form of cell death, contribute to neurodegeneration. To investigate ferroptosis in MPSIIIB, we examined […]